您当前所在位置: 首页» 研究生培养» 导师介绍» 饲用酶工程团队» 苏小运

苏小运

发布者:管理员 发布时间:2019-03-25 作者: 来源: 点击量:

  苏小运,男,研究员,博士生导师,入选中国农科院“青年英才”人才计划。

  教育背景

    1996-2000年,西南农业大学动物科技学院,兽医学,本科
      2000-2003年,南京农业大学动物医学院,预防兽医学,硕士
      2005-2009年,中国科学院微生物研究所,生物化学与分子生物学,博士

  工作经历

     2003-2005年,重庆瑞康生物技术有限公司,助理科学家
       2009-2012年,美国伊利诺伊大学香槟分校Energy Biosciences Institute,博士后
       2012-2014年,新加坡科技研究局Metabolic Engineering Research Laboratory,研究科学家
       2014年至今,中国农业科学院饲料研究所,研究员,入选中国农科院“青年英才”人才计划

  研究领域

  酶是专一性很强的生物催化剂,被广泛应用于饲料、食品、化工等行业。木质纤维素的高效酶学降解,是当今我们所处的第三次生物技术浪潮-即白色工业生物技术浪潮所研究的热点领域之一。我组围绕木质纤维素的高效降解,从酶机制、酶表达和酶应用三个方面分别展开研究,具体包括:

  1. 木质纤维素降解的分子酶学机制:研究内容包括白腐真菌降解木质纤维素的分子机制;裂解性多糖单氧化酶LPMOs;糖苷水解酶等。
       2. 真菌高效表达系统:采用CRISPR-Cas9等现代分子生物学技术,对里氏木霉、黑曲霉等展开基因工程改造,提高其产酶能力。
       3. 合成生物学与代谢工程:高效利用农业废弃物如秸秆资源,构建和优化新型代谢通路,合成高附加值化学品。

  主持项目

  1. 中国农业科学院“青年英才”启动项目
       2. 国家自然科学基金面上项目
       3. 国家自然科学基金青年基金
       4. 十三五重点研发课题
       5. 中国农业科学院基本科研业务费增量项目
       6. 中国科学院微生物研究所开放课题

  发表文章

  1. Xing Qin#, Xiaoyun Su#*, Huiying Luo, Rui Ma, Bin Yao#, Fuying Ma#. Biochemical, genomic, and transcriptomic analyses of the simultaneous white rot fungus Irpexlacteus reveal a unique mechanism in lignocellulose deconstruction involving sequentially up-regulated expression of relevant enzymes. Submitted to PNAS.

  2. Yindi Chu#, Tao Tu#, LeenaPenttinen, XianliXue, Xiaoyun Wang, Zhuolin Yi, Li Gong, JuhaRouvinen, Huiying Luo, Nina Hakulinen*, Bin Yao*, Xiaoyun Su*. Structural and mutation insights into the roles of the non-catalytic residues for a GH10 xylanase with cellulase activity. Submitted to Journal of Biological Chemistry.

  3. Xianhua Sun, XianliXue, Mengzhu Li, Fei Gao, ZhenzhenHao, Huoqing Huang, Huiying Luo, Bin Yao*, Xiaoyun Su*. Efficient co-production of mannanase and cellulase by transformation of a codon-optimized endo-mannanase gene from Aspergillusniger into Trichodermareesei. Submitted to Journal of Agricultural and Food Chemistry.

  4. Yilan Wu, Xianhua Sun, XianliXue, Huiying Luo, Bin Yao, XiangmingXie, Xiaoyun Su*. Engineering key component genes of the secretion pathway for enhanced expression of an Aspergillusniger glucose oxidase in Trichodermareesei. Accepted by Enzyme and Microbial Technology.

  5. Xing Qin, Xianhua Sun, Huoqing Huang, Yingguo Bai, Yuan Wang, Huiying Luo, Bin Yao*, Xiaoyu Zhang*, Xiaoyun Su*. Oxidation of a non-phenolic lignin model compound by two Irpexlacteus manganese peroxidases: evidence for implication of carboxylate and radicals. Biotechnology for Biofuels. Accepted. IF="6.444

  6. XianliXue,Yilan Wu,Xing Qin,Rui Ma,Huiying Luo,Xiaoyun Su*, Bin Yao*. Revisiting overexpression of a heterologous β-glucosidase in Trichodermareesei : the Neosartoryafischeri Bgl3A enhances the overall as well as individual cellulase activities. Microbial Cell Factories, 2016,15:122. IF="4.220

  7. Rong Wang,XianliXue, Rui Ma, Huiying Luo, Bin Yao*, Xiaoyun Su*.Identification of the C-terminal GH5 domain from CbCel9B/Man5A as the first glycoside hydrolase with thermal activation property from a multimodularbifunctional enzyme. PLoS ONE 11(6):e0156802.. IF="3.234

  8. Hongfang Zhang#, Xiukai Li#, Xiaoyun Su#, EeLuiAng, Yugen Zhang, Huimin Zhao. Production of adipicacid from sugar beet residue by combined biological and chemical catalysis. ChemCatChem. DOI: 10.1002/cctc.201600069. IF="4.556

  9. Di Liang, Li Gong, Bin Yao, XianliXue, Xing Qin, Rui Ma, Huiying Luo, XiangmingXie, Xiaoyun Su. Implication of a galactomannan-binding GH2 b-mannosidase inmannan utilization by Caldicellulosiruptorbescii . Biochemical and Biophysical Research Communications 2015, 467:334-340. IF="2.297

  10. Ke Li, Kun Meng, Xia Pan, Rui Ma, Peilong Yang, Huoqing Huang, Bin Yao,Xiaoyun Su. Two thermophilic fungal pectinases from Neosartoryafischeri P1:Gene cloning, expression, and biochemical characterization.Journal of Molecular Catalysis B: Enzymatic 2015,118:70–78. IF="2.128

  11. XianliXue, Rong Wang, Tao Tu, Pengjun Shi, Rui Ma, Huiying Luo, Bin Yao*, Xiaoyun Su*. The N-terminal GH10 domain of a multimodular protein from Caldicellulosiruptorbescii is a versatile xylanase/b-glucanase that can degrade crystalline cellulose. Applied and Environmental Microbiology.2015,81(11):3823-3833. IF="3.668

  12. Xin Dai#, Yan Tian#, Jinting Li#, Xiaoyun Su#, Xuewei Wang, Shengguo Zhao, Li Liu, Yingfeng Luo, Di Liu, Huajun Zheng, Jiaqi Wang, Zhiyang Dong, Songnian Hu*, Li Huang*. Metatranscriptomic analyses of plant cell wall polysaccharide degradation by microorganisms in cow rumen, Applied and Environmental Microbiology.2015,81(4):1375-1386. IF="3.668

  13. Xiaoyun Su#, Lina Qin#, Zhiyang Dong. Biotechnology and Biology of Trichoderma . Chapter 15: RNAi-mediated gene silencing in Trichoderma spp.-principles and applications. 2014,215-226. Elsevier,in book Biotechnology and Biology of Trichoderma . http://dx.doi.org/10.1016/B978-0-444-59576-8.00015-1. Book chapter.

  14. Xiaoyun Su, Yejun Han, Dylan Dodd, Young Hwan Moon, Shosuke Yoshida, Roderick I. Mackie, and Isaac K. O. Cann. Reconstitution of a thermostable xylan-degrading enzyme cocktail from Caldicellulosiruptorbescii . Applied and Environmental Microbiology. 2013,79(5): 1481-1490. IF="3.678

  15. Mingzi Zhang#, Xiaoyun Su#, EeLuiAng, Huimin Zhao. Recent advances in biocatalysts engineering. Pharmaceutical Bioprocessing 2013,1(2): 179-196. New journal.

  16. Xiaoyun Su*, George Schmitz*, Meiling Zhang, Roderick I. Mackie, and Isaac K. O. Cann. Heterologous gene expression in filamentous fungi, Advances in Applied Microbiology. 2012,81: 1-61. IF="5.233

  17. Xiaoyun Su, Jing Zhang, Roderick I. Mackie, and Isaac K. O. Cann. Supplementing with non-glycoside hydrolase proteins enhances enzymatic deconstruction of plant biomass, PLoS ONE. 2012,7(8): e43828. IF="4.092

  18. Xiaoyun Su, Roderick I. Mackie, and Isaac K. O. Cann. Biochemical and mutational analyses of a multi-domain cellulase/mannanase from Caldicellulosiruptorbescii . Applied and Environmental Microbiology 2012,78(7):2230-2240. IF="3.829

  19. Xiaoyun Su, Vinayak Agarwal, Dylan Dodd, Brian Bae, Roderick I. Mackie, Satish K. Nair, and Isaac K. O. Cann. Mutational insights into the roles of amino acid residues in ligand binding for two closely related family 16 carbohydrate binding modules, Journal of Biological Chemistry, 2010,285(45): 34665-34676. IF="5.328

  20. Xiaoyun Su, Shan Zhang, Li Wang, and Zhiyang Dong. Overexpression of IbpB enhances production of soluble active Streptomyces olivaceovirdis XynB in Escherichia coli . Biochemical and Biophysical Research Communications 2009,390: 673-677. IF="2.648

  21. Xiaoyun Su, Xin Chu, and Zhiyang Dong.Identification of elevated transcripts in a Trichodermareesei strain expressing a chimeric transcription activator using suppression subtractive hybridization. World Journal of Microbiology and Biotechnology 2009,25(6): 1075-1084. IF="0.945

  22. Tao Tu, Kun Meng, Huoqing Huang, Huiying Luo, Yingguo Bai, Rui Ma, Xiaoyun Su, PengjunShi,Peilong Yang, Yaru Wang, and Bin Yao. Molecular characterization of a thermophilicendo-polygalacturonase from Thielaviaarenaria XZ7 with high catalytic efficiency and application potential in the food and feed industries. Journal of Agricultural and Food Chemistry,2014,62, 12686-12694.

  23. Xingliang Pan, Xiuzhen Chen,Xiaoyun Su, Yuan Feng, Yong Tao, Zhiyang Dong. Involvement of SpoVG in hemolysis caused by Bacillus subtilis . Biochemical and Biophysical Research Communications 2014,443(3):899-904.

  24. Zhuolin Yi, Xiaoyun Su, Vanessa Revindran, Roderick I. Mackie, Issac K.O. Cann, Molecular and biochemical analyses of CbCel9A/Cel48A, a highly secreted multi-modular cellulase by Caldicellulosiruptorbescii during growth on crystalline cellulose. PLoS ONE 2013,12(8): e84172.

  25. Libin Ye, Xiaoyun Su, George Schmitz, Young Hwan Moon, Jing Zhang, Roderick I. Mackie, and Isaac K. O. Cann. Molecular and biochemical analyses of the GH44 module of CbMan5B/Cel44A, a bifunctional enzyme from the hyperthermophilic bacterium Caldicellulosiruptorbescii . Applied and Environmental Microbiology 2012,78(19): 7048-7059.

  联系方式:010-82106094,suxiaoyun@caas.cn


打印』『关闭