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发布者:管理员 发布时间:2021-11-24 作者: 来源: 点击量:


第十五届国际乳铁蛋白结构、功能与应用会议”(15th International Conference on Lactoferrin Structure, Function and Applications)将于2021126-10在北京视频举办,这是乳铁蛋白领域的最高国际学术例会。该例会经国际乳铁蛋白会议科学委员会授权,农业农村部批准,由中国农业科学院饲料研究所主办,会议主席为王建华研究员。会议以乳铁蛋白结构、功能及应用为中心,设“乳铁蛋白对冠状病毒的干预作用”等10个主题分享72场报告,约200名会议代表来自26个国家。2009年在北京主办第九届国际乳铁蛋白会议后,乳铁蛋白作为主要配方奶粉和高档动物饲料的核心成分已列入我国官方行业准入目录并制定标准,有效规范和促进了乳铁蛋白研发与应用。预期该例会在我国的再次举办,对拓展乳铁蛋白研发深广度、充分挖掘并发挥其潜在健康保障作用、促进乳铁蛋白学科繁荣并填补我国产品制造空白具重要理论和实际意义。会期五天,工作语言为英语。期待您的参与,会议信息如下。




 Bo Lönnerdal, University of California Davis, USA (Chairman)

 Nidia León-Sicairos, Universidad Autónoma de Sinaloa, Mexico

 Theresa J. Ochoa, Universidad Peruana Cayetano Heredia, Peru

 Katsufumi Otsuki, Showa University Koto Toyosu Hospital, Japan

 Anthony Schryvers, University of Calgary, Canada

 Piera Valenti, University of Rome La Sapienza, Italy

 Vadim Vasilyev, Institute of Experimental Medicine Saint-Petersburg, Russia

 Hans Vogel, University of Calgary, Canada

 Jianhua Wang, Chinese Academy of Agricultural Sciences, P. R. China



 吴孔明 中国农业科学院

 唐华俊 中国农业科学院

 魏宏阳 农业农村部畜牧兽医局

 戴小枫 中国农业科学院饲料研究所


 王建华 中国农业科学院饲料研究所(会议主席)

 杨培龙 中国农业科学院饲料研究所

 滕  中国农业科学院饲料研究所

 毛若雨 中国农业科学院饲料研究所

 杨  中国农业科学院饲料研究所

  Hidefumi Kuwata 日本乳铁蛋白协会

  Hirotsugu Oda日本森永乳业株式会社

  Jean-Paul Perraudin, 比利时塔莱登实验室


 迄今已签约赞助第十五届国际乳铁蛋白结构、功能与应用例会的赞助商有Morinaga、中大恒源、IngrediaFrieslandCampinaSartoriusArmorWestland Milk ProductsBiolactiveValfooNorson等(更新中)。


 BioMetals 2022,客座主编:王建华、Hans Vogel


Opening remarks: (22:00-24:00, 2021. 12. 06) 

President of CAAS

Director of host institute

Chairman of organizing committee


Hans Vogel: Activities of lactoferrin and its derived bioactive peptides. University of Calgary, Canada

Piera Valenti: An overview on in vitro and in vivo antiviral activity of lactoferrin: its efficacy against SARS-CoV-2 infection. University of Rome La Sapienza, Italy  

Session 1: Lactoferrin: cell proliferation, differentiation and neurodevelopment
(7:40-11:10, 2021. 12. 07)

Marian L. Kruzela and Barbara Pazdrakb: A novel human recombinant lactoferrin inhibits lung adenocarcinoma cell growth and migration. a) Pharma Review Corporation, USA; b) The University of Texas MD Anderson Cancer Center, USA

Bing Wang: Molecular characteristics of the dose-response relationship of dietary lactoferrin intervention on neurodevelopment and cognition. Xiamen University, China; Charles Sturt University, Australia

Estefania Massa: Lactoferrin affects fertilization and embryo implantation in rats. Universidad Nacional de Rosario, Argentina 

Vanessa P. Rocha: Bovine lactoferrin induces cell death in human prostate cancer cells. Universidade Federal do Estado do Rio de Janeiro (UNIRIO), Brazil

Serena Eng: Phenotypic effects of lactoferrin on human intestinal organoids. University of California Davis, USA

Daisuke Kurimoto: “Lactoferrin-Meets-Albumin” shows enhanced intracellular delivery. Tokyo University of Technology, Japan

Hana Nopia: Albumin fusion with human lactoferrin displays enhanced inhibition of cancer cell migration. Tokyo University of Technology, Japan 

Ramírez-Sánchez D.A: Deglycosylation of bovine lactoferrin affects the anticancer activity against cervical and colon cancer cell lines. Universidad Autónoma de Sinaloa, Mexico

Session 2: Lactoferrin: immunomodulating activity (11:10-14:10, 2021. 12. 07)

Actor Jeffrey K: Recombinant human lactoferrin reduces inflammation and increases fluoroquinolone penetration to granulomas during mycobacterial infection. McGovern Medical School, USA

Jian Ma: Lactoferrin is required for early B cell development in C57BL/6 mice. Central South University, P. R. China 
Lingyu Wei: Lactoferrin deficiency induces a pro-metastatic tumor microenvironment through recruiting myeloid–derived suppressor cells in mice. Heping Hospital Affiliated to Changzhi Medical College, P. R. China 

Yuexin Shao: Study on the mechanism of lactoferrin synthesis and its immune function. Northwest A&F University, P. R. China 

Shutaro Kubo: Effects of bovine lactoferrin on plasmacytoid dendritic cells in peripheral blood ex vivo. Morinaga Milk Industry Co., Ltd., Japan

Asuka Tada: Lactoferrin innovations in Morinaga Milk Group- past approach and current efforts for people’s health and nutrition. Morinaga Milk Industry Co., Ltd., Japan 

Lourdes Sánchez: Beneficial effects of lactoferrin on inflammation in a murine model of colitis. AgriFood Institute of Aragon; University of Zaragoza, Spain

Session 3: Effects of lactoferrin on coronavirus (20:30-00:50, 2021. 12. 07) 

Elena Campione: Lactoferrin as antiviral treatment in COVID-19 management: preliminary evidence. University of Rome Tor Vergata, Italy 

Hamid Merchant: Lactoferrin supplements, respiratory tract infections and implications in Covid-19. University of Huddersfield, UK 

Luigi Rosa: Binding between lactoferrin and spike glycoproteins: influence on iron and inflammatory homeostasis disorders. University of Rome La Sapienza, Italy 
Alexey Sokolov: Molecular mimicry: antibodies against RBD in the SARS-CoV-2 spike protein interact with transferrin and lactoferrin. Institute of Experimental Medicine, Russia

Theresa J. Ochoa: Bovine lactoferrin for the prevention of COVID-19 infection in health care personnel: a double-blinded randomized clinical trial. Universidad Peruana Cayetano Heredia, Peru 

Paolo Manzoni: A multicentre, double-blind, placebo-controlled randomized clinical trial of oral Bovine Lactoferrin treatment in Covid-19 hospitalized patients: preliminary data. ASLBI and University of Torino, Italy

Carmen Mirabelli: Morphological cell profiling of SARS-CoV-2 infection identifies lactoferrin as candidate for COVID-19. University of Michigan Medical School, USA

Yanmei Hu: The in vitro antiviral activity of lactoferrin against common human coronaviruses and SARS-CoV-2 is mediated by targeting the heparan sulfate co-receptor. The University of Arizona, USA 

Danilo Buonsenso: Role of lactoferrin in the treatment of children with Post-Covid Condition (Long covid): a prospective observational study. Fondazione Policlinico Universitario, Italy 

Session 4: Lactoferrin: from DNA editing, recombinant expression into application in piglets (8:00-10:30, 2021. 12. 08) 

Jing Wang: Effects of early-life lactoferrin intervention on growth performance, intestinal function and gut microbiota in suckling piglets. Nanjing Agricultural University, P. R. China
Lijie Tang: Mechanism of Lactobacillus reuteri from piglets secreting bovine lactoferrin peptides to enhance the intestinal mucosal immunity. Northeast Agricultural University, P. R. China 

Shengsong Xie: Enhancing the antibacterial activities of sow milk via site-specific knock-in of a lactoferrin gene in pigs. Huazhong Agricultural University, P. R. China 

Xuanxuan Ma: Effects of dietary supplementation of bovine lactoferrin on growth performance, intestinal health in weaning piglets. Chinese Academy of Agricultural Sciences, P. R. China 

Limeng Cai: Recombinant piglet source Lactobacillus reuteri secreting expression of lactoferrin peptides on growth performance of newborn piglets and protective effect against diarrhea virus infection. Northeast Agricultural University, P. R. 

Xueying Wang: Microencapsulation of bovine lactoferricin- lactoferrampin- encoding Lactobacillus reuteri CO21 enhances mucosal immunity of piglets against Salmonella typhimurium SL1344 infection. Northeast Agricultural University, P. R. China

Session 5: Standardization of lactoferrin products (11:00-14:00, 2021. 12. 08)

Bo Lönnerdal: Biological activities of commercial bovine lactoferrin sources. University of California Davis, USA 

Nan Zheng: Detection of lactoferrin in dairy products and its contribution to the standard of lactoferrin. Chinese Academy of Agricultural Sciences, P.R. China 

Da Teng: Interpretation of the national food safety standard of lactoferrin. Chinese Academy of Agricultural Sciences, P. R. China 

Jefferson Wang: Technology innovation for a better product-Zhongda PUCUMIN®. Henan Zhongda Hengyuan Biotechnology Stock Co., Ltd., P. R. China 

Hidefumi Kuwata: A review of new health benefits of lactoferrin: A perspective on the market potential in the next decade. NRL Pharma, Inc., Japan

Jean Paul Perraudin: Relatious between quality and biological activities of bovine lactoferrin. Taradon-Laboratory, Belgium  

Session 6: Lactoferrin: effectiveness for development of neonatal and health of infertile, pregnant and breast-feed women (20:00-23:50, 2021. 12. 08) 

Bing Wang: Molecular characteristics of the dose-response relationship of dietary lactoferrin intervention on neurodevelopment and cognition.Xiamen University, China; Charles Sturt University, Australia 

Katsufumi Otsuki: Verification of lactoferrin: prevention of pregnant loss and promotion of healthy child development. Showa University Koto Toyosu Hospita, Japan 

Momoko Miyakawa: Research review: usefulness of lactoferrin in infant/child health. Morinaga Milk Industry Co., Ltd. Japan  

Sanches Eduardo: Dose-dependent neuroprotective effects of bovine lactoferrin following neonatal hypoxia-ischemia in the immature rat brain. University of Geneva, Switzerland  

Theresa J. Ochoa: Is lactoferrin still a treatment option for neonatal sepsis? Universidad Peruana Cayetano Heredia, Peru 

Nidia León-Sicairos: Lactoferrin level in children with cancer complicated with sepsis and nutrition.  Universidad Autónoma de Sinaloa, Mexico

Uriel A. Angulo-Zamudio: Plasma lactoferrin levels in newborn infants with early-onset neonatal sepsis. Autonomous University of Sinaloa, Mexico

Jennifer Bermick: Bacterial growth inhibition of common neonatal pathogens differs markedly between bovine lactoferrin preparations. University of Iowa, USA

Session 7: Lactoferrin characterization, bioavailability and bioequivalence (14:30-17:20, 2021. 12. 08) 

Vadim Vasilyev: Protective effect of recombinant lactoferrin in a rat model of myocardial infarction. Institute of Experimental Medicine, Russia 

Sebastian P. Galuska: The impact of glycosylation on the function of lactoferrin. Research Institute for Farm Animal Biology (FBN), Germany 

Jingyuan Wen: Enhance lactoferrin oral absorption using nanotechnology. University of Auckland, New Zealand 

Nikolay Bunenkov: Lactoferrin blood plasma level after coronary artery bypass grafting. First State Pavlov Medical University of the Ministry of Healthcare of the Russian Federation, Russia 

Maxim Kiryukhin: Lactoferrin microencapsulation for enhanced bioavailability. Singapore Institute of Food and Biotechnology Innovation, A*STAR, Singapore

Masao Nakamura: Human lactoferrin as a neutralizer of axonal growth inhibition by glycan. Sasaki Institute, Japan

Jianhua Wang: Coating of lactoferrin and its improvement on bioactivity. Chinese Academy of Agricultural Sciences, P. R. China

Session 8: Antimicrobial effects of lactoferrin (18:20-20:40, 2021. 12. 09)

Dee Carter: Lactofungin: a novel antifungal synergent. University of Sydney, Australia 

Antimo Cutone: Bovine lactoferrin affects HIV-Tat-induced oxidative stress and neurotoxicity. University of Molise, Italy.

Cátia Santos-Pereira: A multidisciplinary approach to untangle the mechanisms behind the antifungal activity of lactoferrin. University of Minho, Portugal 

Dimitra Graikini Evangelinou: Evaluation of in vitro antirotaviral activity of lactoferrin from different species using a human intestinal model.University of Zaragoza, Spain 

Kraaij Saskia: Lactoferrin and the development of salivary stones. Academic Center for Dentistry Amsterdam, Netherlands 

Inés Abad: Effect of technological treatments and in vitro gastrointestinal digestion on the antibacterial activity of bioactive milk formulas supplemented with lactoferrin. Universidad de Zaragoza, Spain  

Session 9: Lactoferrin-bacterial interactions and infectious diseases (23:10-01:20, 2021. 12. 09)

Anthony Schryvers: Structural characteristics of the interaction between bacterial lactoferrin binding protein B and lactoferrin or its byproduction. University of Calgary, Canada

Ruben Ongena: Effect of lactoferrin on the immune response against shigatoxin-producing Escherichia coli infection in piglets. Gent Universiteit, Belgium  

Lucero Ruiz-Mazón: Effect of bovine lactoferrin on adhesion and biofilm formation of Mannheimia haemolytica A2: in silico study. Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Mexico 

Laura Quintero: Effect of bovine lactoferrin and lactoferrin-peptides on Salmonella biofilms on abiotic surfaces or Caco-2 cells. Universidad Autónoma de Sinaloa, Mexico

Gerardo Ramírez-Rico: Effect of lactoferrin on the pathogenicity mechanisms of bacteria. Centro de Investigación y de Estudios Avanzados, Mexico 

Clement Chan: The role of Moraxella catarrhalis CopB in iron acquisition from human lactoferrin and transferrin. University of Calgary, Canada 

Session 10: Native lactoferrin and its derived peptides (21:00-23:10, 2021. 12. 10) 

Dielson da S. Vieira: An in silico, Structural, and Biological Analysis of Lactoferrin from Goats. Sao Paulo State University “Júlio de Mesquita Filho” (UNESP), Brazil 

Na Yang: A cleavable lactoferrin chimeric peptide enhances LPS neutralization and antibacterial properties against MDR E. coli. Chinese Academy of Agricultural Sciences, P. R. China

Thomas Hopp: Proteolytic degradation of vaginally administered bovine lactoferrin. Metrodora Therapeutics LLC, USA 

Amilkar I. Araujo-Bedoya: Influence of bovine lactoferrin, Lactoferricin17-30, Lactoferrampin265-284, Lactoferrin Chimera and Glucose on virulence factors in an Azole-Resistant clinical isolate of Candida Albicans. Universidad Autónoma de Sinaloa, Mexico 

Izamar G. Arredondo-Beltrán: Effect of bovine lactoferrin and LF chimera in Klebsiella pneumoniae extended spectrum β-lactamases multi-drug-resistant. Universidad Autónoma de Sinaloa, Mexico 

Hans Vogel: Selective anticancer activities of Trp- and Arg-rich antimicrobial peptides. University of Calgary, Canada

Closing remarks (23:10-24:00, 2021. 12. 10)

Announcing youth scientist award

Announcing next host city

Other issues




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