Resistance and pathogenicity of Salmonella Thompson isolated from incubation end of a poultry farm
Recently, researchers from Veterinary Medicines and Immunomodulators Innovation Research Team of the Institute of Feed Research of CAAS studied the drug resistance of clinical Salmonella Thompson and its pathogenicity to poultry. These results are of great significance to evaluate the drug-resistant transmission ability of Salmonella Thompson and it's harm to poultry breeding.
Non-typhoid Salmonella is the general term of Salmonella which often causes foodborne gastroenteritis in humans, but some serotypes have been proved to be pathogenic to poultry. During Salmonella surveillance in farms, the Salmonella Thompson, a common Non-typhoid Salmonella , was also pathogenic to avian embryos was discovered. Therefore, this study aimed to explore antimicrobial resistance and pathogenicity of clinical S. Thompson. Evolutionary analysis, molecular typing, antimicrobial resistance, and virulence genes based on WGS were performed on 14 clinical S . Thompson strains.Antimicrobial sensitivity tests for 18 antibiotics and bacterial inoculation experiments on one-day-old chicks were conducted. Three conclusions were obtained : 1) The significant decrease in embryo hatching rate in this farm was caused by S. Thompson, which was highly pathogenic to newborn chicks; 2) fourteen clinical S. Thompson strains originated from the same clone, and the colistin (polymyxin B) resistance gene mcr-9 was reported for the first time in S. Thompson; 3) the identical cgST-12774 typing of S. Thompson of human was observed in avian origin.
This work was supported by the National Key R&D Program "Integrated Re-search and Optimization of Green Quality Assurance Technology for Broilers" (Grant No. 2018YFD0500403) and the Agricultural Science and Technology Innovation Program (Grant No.FRI-06).Original link: https://www.mdpi.com/2306-7381/9/7/349