皮宇
发布时间:2026-08-20
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皮宇 猪营养与饲料创新团队
piyu@caas.cn
安徽泗县人,中共党员,2019年毕业于南京农业大学,获博士学位。中国农业科学院饲料研究所副研究员、硕士生导师;入选中国农业科学院所级青年英才;农业农村部饲料合成生物技术重点实验室学术委员会委员。
学习和工作经历
2008.09~2012.07 安徽科技学院 动物科学专业 本科生
2012.09~2015.07 扬州大学 动物营养与饲料科学专业 硕士生
2013.07~2015.03 中国农业科学院北京畜牧兽医研究所 客座硕士生
2015.09~2019.07 南京农业大学 动物营养与饲料科学专业 博士生
2019.09~2021.07 中国农业大学 & 播恩集团股份有限公司 博士后
2021.07~2022.12 中国农业科学院饲料研究所 助理研究员
2023.01~至今 中国农业科学院饲料研究所 副研究员
科研情况:
主要从事猪消化道微生物研究,聚焦消化道微生物及代谢产物对母猪繁殖性能、仔猪肠道健康的调控机制,基于研究成果开发相关营养调控策略与微生态产品,为猪健康绿色养殖提供科技支撑。先后主持国家自然科学基金项目(青年、面上)、国家重点研发计划项目子课题、中国博士后科学基金面上项目、河北省农业科技成果转化项目、中国农科院创新工程及院企合作项目等科研项目20余项;以第一或通讯作者在Microbiome、Animal Nutrition等权威期刊发表SCI论文30余篇;授权国家发明专利5件;获河北省科学技术成果1项、杨胜营养科技创新奖1项、中国畜牧兽医学会动物营养学分会第八届青年学者论坛优胜奖1项。受邀担任Frontiers in Microbiology杂志副主编、ISME Journal杂志编委。
代表性成果:
[1] Pi Y., Wu Y.J., Zhang X.Y., Lu D.D., Han D.D., Zhao J.C., Zheng X.J., Zhang S.Y., Ye H., Lian S., Bai Y., Wang Z.Y., Tao S.Y., Ni D.J., Zou X.H., Jia W., Zhang G.L., Li D.F., Wang J.J.* (2023). Gut microbiota-derived ursodeoxycholic acid alleviates low birth weight-induced colonic inflammation by enhancing M2 macrophage polarization. Microbiome, 11: 19.
[2] Pi, Y.,* Wei, Z.X., Xu, L., Yin, C.G., Li, Y.P., Li X.L.* (2026). Structural and functional characteristics of faecal, vaginal and colostrum microbiota in high-yielding sows. Microbial Genomics, 12(3), 001627.
[3] Xu, L., Yin, C.G., Fan, Y.Y., Yang, J.Q., Ming, D.X., Sun, W.J., Li, Y.P., Li X.L., Pi, Y.* (2026). Taurine mitigates bisphenol A-induced maternal-fetal oxidative stress and improves fetal weight by regulating Nrf2-Keap1 pathway, gut microbiota and bile acid metabolism. Food & Function, 17(9),4213-4230.
[4] Pi, Y., Mu, C.L., Gao, K., Liu, Z., Peng, Y., Yu, K.F., Su, Y., Zhu, W.Y.* (2025). Increasing carbohydrates or nitrogenous compounds by cecal infusion leads to an opposite influence on colonic microbiota and host metabolism in a pig model. Animal Nutrition, 23: 62-77.
[5] Yin, C.G., Xu, L., Wei, Z.X., Zhao, Y., Bai, R., Gao, G., Fan, Y.Y., Li, Y.P., Sun, W.J., Li X.L.,* Pi, Y.* (2025). Gut microbiota and bile acid profiles in purebred vs. crossbred sows: links to oxidative stress and inflammation in late gestation. Microbial Genomics, 11(12), 001579.
[6] Pi Y, Zhang X.Y., Wu Y.J., Wang Z.Y., Bai Y, Liu X.Y., Han D.D., Zhao J.B., Tobin I, Zhao J.C., Zhang G.L., Wang J.J.* (2022). Alginate alleviates dextran sulfate sodium-induced colitis by promoting Bifidobacterium animalis and intestinal hyodeoxycholic acid synthesis in mice. Microbiology Spectrum, 10: e0297922.
[7] Pi Y., Mu C.L., Gao K., Liu Z., Peng Y., Zhu W.Y.* (2020). Increasing the hindgut carbohydrate/protein ratio by cecal infusion of corn starch or casein hydrolysate drives gut microbiota-related bile acid metabolism to stimulate colonic barrier function. mSystems, 5: e00176-20.
[8] Ming D.X., Xu X.C., Jiang X.R., Li Y.P., Sun W.J., Xiang J.B., Huang M.Y., Pi Y.,* Li X.L.* (2024) Indole-3-propionic acid enhances growth performance and reduces diarrhea via modulating redox status and intestinal inflammation in weaned piglets. Animal Nutrition, 19: 240-247.
[9] Han, R.Y., Ouyang, L.M., Yin, C.G., Cai, L., Wu, Q., Chen, L., Du, J., Li X.L., Zhu Z.G.,* Pi, Y.* (2025). Supplementation of low-protein diets with plant protein and probiotics enhances muscle health by regulating gut microbiota and metabolomic profiles in SAMP8 mice. Food & Function, 16(11), 4575-4592.
[10] Xu L., Wei Z.X., Guo Y., Guo B.Z., Cai L., Yan J., Ma L.H., Sun W.J., Li Y.P., Jiang X.R., Li X.L.,* Pi Y.* (2024). Effects of dietary supplementation with fermented flaxseed meal on the growth performance, immune function, and intestinal microbiota of growing pigs. Animal Feed Science and Technology, 316: 116079.
[11] Xu L., Li Y.P., Wei Z.X., Bai R., Gao G., Sun W.J., Jiang X.R., Wang J.J., Li X.L.,* Pi Y.* (2022) Chenodeoxycholic acid (CDCA) promoted intestinal epithelial cell proliferation by regulating cell cycle progression and mitochondrial biogenesis in IPEC-J2 cells. Antioxidants (Basel), 11: 2285.
[12] 国家发明专利:皮宇, 李习龙, 孟昆, 蒋显仁, 杨培龙, 孙文娟, 李彦品, 徐蕾. 一种亚麻籽粕的发酵方法、日粮. 专利号ZL202311641416.7, 授权公告日2025-05-30.
[13] 国家发明专利:皮宇, 李习龙, 蒋显仁, 徐蕾, 孙文娟, 李彦品. UDCA用于制备降低妊娠猪胎儿宫内发育迟缓发生率的制剂的应用及饲料. 专利号ZL2023105003433, 授权公告日2025-12-02.
[14] 国家发明专利:皮宇, 李习龙, 殷成港, 徐蕾, 李彦品, 孙文娟, 明东旭. 3-oxoLCA在降低妊娠母体及其子代的氧化应激和炎症中的应用. 专利号ZL202511788439.X, 授权公告日2026-04-14.
[15] 国家发明专利:王军军, 皮宇, 韩丹丹, 武玉珺, 陆东东. 熊脱氧胆酸在缓解宫内生长受限所致低出生体重仔猪生长抑制中的应用. 专利号ZL202111088909.3, 授权公告日2024-09-06.